Protein kinases orchestrate progression through the cell cycle by reversible phosphorylation of substrates that control DNA replication, mitotic entry, spindle assembly, and cytokinesis.

The eukaryotic cell cycle is orchestrated by a series of tightly regulated transitions that ensure faithful replication and segregation of genetic material. Progression through G1, S, G2 and M phases ...

The review emphasizes how breakthroughs in understanding the molecular mechanisms of cell cycle regulation have paved the way for the development of targeted anti-cancer agents. Notably, inhibitors of ...